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Article

A gene-coexpression network for global discovery of conserved genetic modules.

Science (New York, N.Y.) - 10 Oct 2003

Stuart Joshua M, Segal Eran, Koller Daphne, Kim Stuart K

Abstract excerpt

To elucidate gene function on a global scale, we identified pairs of genes that are coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found 22,163 such coexpression relationships, each of which has been conserved across evolution. This conservation implies that the coexpression of these gene pairs confers a selective advantage and therefore that these genes are functionally related....

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Identifiers

PMID: 12934013
DOI: 10.1126/science.1087447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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