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Article

Fibroblast growth factor-2 deficiency causes defects in adult hippocampal neurogenesis, which are not rescued by exogenous fibroblast growth factor-2.

Journal of neuroscience research - 1 Oct 2011

Werner Sandra, Unsicker Klaus, von Bohlen und Halbach Oliver

Abstract excerpt

Neurogenesis within the adult brain is restricted to selected areas, one of which is the dentate gyrus (DG). Several growth factors have been reported to affect neurogenesis in the adult DG. However, a role of fibroblast growth factor-2 (FGF-2) in adult hippocampal neurogenesis has not been firmly established. We have analyzed neurogenesis in the DG using in vivo and in vitro approaches. FGF-2(-/-) mice revealed...

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PMID: 21800348
DOI: 10.1002/jnr.22680

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