Article
Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype.
Cell death & disease - 3 Dec 2015
Anzilotti S, Tornincasa M, Gerlini R, Conte A, Brancaccio P, Cuomo O, Bianco G, Fusco A, Annunziato L, Pignataro G, Pierantoni G M
Abstract excerpt
Homeodomain-interacting protein kinase 2 (HIPK2) is a multitalented coregulator of an increasing number of transcription factors and cofactors involved in cell death and proliferation in several organs and systems. As Hipk2(-/-) mice show behavioral abnormalities consistent with cerebellar dysfunction, we investigated whether Hipk2 is involved in these neurological symptoms. To this aim, we characterized the...
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