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Article

IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients

5 Jan 2010

Abstract excerpt

BACKGROUND: Insulin-like growth factor-1 (IGF-I) signalling is important for cancer initiation and progression. Given the emerging evidence for the role of the stroma in these processes, we aimed to characterize the effects of IGF-I on cancer cells and stromal cells separately. METHODS: We used an ex vivo culture model and measured gene expression changes after IGF-I stimulation with cDNA microarrays. In vitro...

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PMID: 20051100
DOI: 10.1186/1741-7015-8-1

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