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Article

Extensive rewiring of epithelial-stromal co-expression networks in breast cancer

18 Jun 2015

Abstract excerpt

BACKGROUND: Epithelial-stromal crosstalk plays a critical role in invasive breast cancer pathogenesis; however, little is known on a systems level about how epithelial-stromal interactions evolve during carcinogenesis. RESULTS: We develop a framework for building genome-wide epithelial-stromal co-expression networks composed of pairwise co-expression relationships between mRNA levels of genes expressed in the...

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PMID: 26087699
DOI: 10.1186/s13059-015-0675-4

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