Article
Interleukin-10 (IL10) promoter polymorphisms and multiple sclerosis.
Journal of neuroimmunology - 15 Nov 1999
Pickard C, Mann C, Sinnott P, Boggild M, Hawkins C, Strange R C, Hutchinson I V, Ollier W E, Donn R P
Abstract excerpt
Interleukin-10 (IL10) is an anti-inflammatory cytokine which may modulate disease expression in multiple sclerosis (MS). Three dimorphic polymorphisms within the IL10 promoter region at positions - 1082, -819 and -519 have previously been identified. The - 1082*A allele has been associated with low and the - 1082*G allele with high in vitro IL10 production. We have genotyped 185 Caucasian MS patients and 211...
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