Article
Selection and analysis of mutations in an encephalomyocarditis virus internal ribosome entry site that improve the efficiency of a bicistronic flavivirus construct.
Journal of virology - 1 Nov 2007
Orlinger Klaus K, Kofler Regina M, Heinz Franz X, Hoenninger Verena M, Mandl Christian W
Abstract excerpt
Flaviviruses have a positive-stranded RNA genome, which simultaneously serves as an mRNA for translation of the viral proteins. All of the structural and nonstructural proteins are translated from a cap-dependent cistron as a single polyprotein precursor. In an earlier study (K. K. Orlinger, V. M...
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