Article
Exploiting Internal Ribosome Entry Sites in Gene Therapy Vector Design
1 Mar 2004
Abstract excerpt
Efficient and regulated co-expression of multiple genes is an important consideration in the design of gene therapy vectors. While the augmentation of a single therapeutic gene is often sufficient for gene therapy of simple mendelian disorders, strategies for the treatment of complex disorders and infectious diseases necessitate the introduction of multiple genes into the cell. Complex disorders such as cancer...
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