Knockdown of <scp>S</scp>ec8 promotes cell‐cycle arrest at <scp>G</scp>₁/<scp>S</scp> phase by inducing p21 via control of <scp>FOXO</scp> proteins

Abstract excerpt

p21(Cip1) protein inhibits the activity of cyclins at the G(1) checkpoint and influences transition of cells from the G(1) to the S phase of the cell cycle. Moreover, expression of members of the FOXO family (active form of forkhead transcription factors of the O class) in dividing cells promotes cell-cycle arrest at the G(1)/S boundary via regulation of p21(Cip1). Recently, the exocyst complex, including Sec8,...

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