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Article

Gamma-irradiation induces matrix metalloproteinase II expression in a p53-dependent manner

1 Apr 2000

Abstract excerpt

Matrix metalloproteinases (MMPs) are a family of proteinases that degrade the basement membrane and have been implicated in promoting tumor metastasis. MMP-2, one member of this family, was recently found to be a p53 target and subject to p53 upregulation. In this study, we examined the correlation between the expression of MMP-2 and the increased expression of p53 after gamma-irradiation. Three human...

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PMID: 10747288
DOI: 10.1002/(sici)1098-2744(200004)27:4<252::aid-mc2>3.0.co;2-3

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