Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma.

Abstract excerpt

Retinoblastoma is a pediatric retinal tumor initiated by biallelic inactivation of the retinoblastoma gene (RB1). RB1 was the first identified tumor suppressor gene and has defined roles in the regulation of cell cycle progression, DNA replication, and terminal differentiation. However, despite the abundance of work demonstrating the molecular function and identifying binding partners of pRb, the challenge facing...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genes, Retinoblastoma
• Share to Cell Cycle
• Share to Disease Models, Animal