The retinoblastoma gene: its role in cell cycle and cancer.

Abstract excerpt

The retinoblastoma gene is the prototype of the tumor suppressor genes, which play critical roles in the genesis of cancer in humans. Although the precise function of the retinoblastoma gene product remains unknown, recent data suggests that it plays dual roles in gating cell cycle progression and promoting cellular differentiation. The molecular mechanisms involved in these roles are becoming clear in some...

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