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Article

Synthesis of nucleotide analogues by a promiscuous phosphoribosyltransferase.

Organic letters - 11 Oct 2007

Scism Robert A, Stec Donald F, Bachmann Brian O

Abstract excerpt

An Escherichia coli strain overexpressing a mutant variant of a phosphoribosyl transferase was developed as a catalyst for the efficient preparation of a range of purine nucleotide analogues. This system offers an efficient and rapid method for nucleotide analogue synthesis with 100% beta-selecti...

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Identifiers

PMID: 17854193
DOI: 10.1021/ol7016802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17854193-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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