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Article

Broadening the scope of glycosyltransferase-catalyzed sugar nucleotide synthesis.

Proceedings of the National Academy of Sciences of the United States of America - 7 May 2013

Gantt Richard W, Peltier-Pain Pauline, Singh Shanteri, Zhou Maoquan, Thorson Jon S

Abstract excerpt

We described the integration of the general reversibility of glycosyltransferase-catalyzed reactions, artificial glycosyl donors, and a high throughput colorimetric screen to enable the engineering of glycosyltransferases for combinatorial sugar nucleotide synthesis. The best engineered catalyst from this study, the OleD Loki variant, contained the mutations P67T/I112P/T113M/S132F/A242I compared with the OleD...

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Identifiers

PMID: 23610417
DOI: 10.1073/pnas.1220220110
PMCID: PMC3651490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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