Article
Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor.
Microbial cell factories - 27 Jul 2020
Black William B, Aspacio Derek, Bever Danielle, King Edward, Zhang Linyue, Li Han
Abstract excerpt
BACKGROUND: Noncanonical redox cofactors are emerging as important tools in cell-free biosynthesis to increase the economic viability, to enable exquisite control, and to expand the range of chemistries accessible. However, these noncanonical redox cofactors need to be biologically synthesized to achieve full integration with renewable biomanufacturing processes. RESULTS: In this work, we engineered Escherichia...
Topics
- Biocatalysis
- Biosynthetic Pathways
- DNA, Bacterial
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Industrial Microbiology
- Metabolic Engineering
- Mutation
- NAD
- Nicotinamide Mononucleotide