Article
The Mcf1 toxin induces apoptosis via the mitochondrial pathway and apoptosis is attenuated by mutation of the BH3-like domain.
Cellular microbiology - 1 Oct 2007
Dowling Andrea J, Waterfield Nicholas R, Hares Michelle C, Le Goff Gaëlle, Streuli Charles H, ffrench-Constant Richard H
Abstract excerpt
Photorhabdus are Gram-negative, nematode-vectored bacteria that produce toxins to kill their insect hosts. The expression of one of these, Makes caterpillars floppy 1 (Mcf1), is sufficient to allow Escherichia coli to survive within, and kill, caterpillars which are otherwise able to clear E. coli infection. Mcf1 treated caterpillars show rapid loss of body turgor (the 'floppy' phenotype) and death is associated...
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