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Article

Hepatitis B virus X protein targets the Bcl-2 protein CED-9 to induce intracellular Ca2+ increase and cell death in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 6 Nov 2012

Geng Xin, Harry Brian L, Zhou Qinghua, Skeen-Gaar Riley Robert, Ge Xiao, Lee Eui Seung, Mitani Shohei, Xue Ding

Abstract excerpt

HBx is a multifunctional hepatitis B virus (HBV) protein that is crucial for HBV infection and pathogenesis and a contributing cause of hepatocyte carcinogenesis. However, the host targets and mechanisms of action of HBx are poorly characterized. We show here that expression of HBx in Caenorhabditis elegans induces both necrotic and apoptotic cell death, mimicking an early event of liver infection by HBV. Genetic...

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Identifiers

PMID: 23091037
DOI: 10.1073/pnas.1204652109
PMCID: PMC3494929

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