Article
Evolutionarily conserved cytoprotection provided by Bax Inhibitor-1 homologs from animals, plants, and yeast.
Gene - 24 Dec 2003
Chae Han-Jung, Ke Ning, Kim Hyung-Ryong, Chen Shaorong, Godzik Adam, Dickman Martin, Reed John C
Abstract excerpt
Programmed cell death (PCD) plays important roles in the development and physiology of both animals and plants, but it is unclear whether similar mechanisms are employed. Bax Inhibitor-1 (BI-1) is an intracellular multi-membrane-spanning protein and cell death inhibitor, originally identified by a function-based screen for mammalian cDNAs capable of suppressing cell death in yeast engineered to ectopically...
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