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Article

N-(3-oxo-acyl) homoserine lactone induced germ cell apoptosis and suppressed the over-activated RAS/MAPK tumorigenesis via mitochondrial-dependent ROS in C. elegans.

Apoptosis : an international journal on programmed cell death - 1 Dec 2018

Chen Bin, Cao Xianbin, Lu Huayi, Wen Pengbo, Qi Xiaojing, Chen Shaopeng, Wu Lijun, Li Chi, Xu An, Zhao Guoping

Abstract excerpt

As a quorum-sensing molecule for bacteria-bacteria communication, N-(3-oxododecanoyl)-homoserine lactone (C12) has been found to possess pro-apoptotic activities in various cell culture models. However, the detailed mechanism of how this important signaling molecule function in the cells of live animals still remains largely unclear. In this study, we systematically investigated the mechanism for C12-mediated...

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Identifiers

PMID: 30171376
DOI: 10.1007/s10495-018-1478-3

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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