Katanin inhibition prevents the redistribution of gamma-tubulin at mitosis.

Abstract excerpt

Katanin is a microtubule-severing protein that is concentrated at mitotic spindle poles but katanin's function in the mitotic spindle has not been previously reported. Inhibition of katanin with either of two dominant-negative proteins or a subunit-specific antibody prevented the redistribution of gamma-tubulin from the centrosome to the spindle in prometaphase CV-1 cells as assayed by immunofluorescence...

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