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Article

Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2008

König Ovidiu, Rüttiger Lukas, Müller Marcus, Zimmermann Ulrike, Erdmann Bettina, Kalbacher Hubert, Gross Manfred, Knipper Marlies

Abstract excerpt

Megalin, the largest member of the low-density lipoprotein receptor-related protein family, functions as an endocytic receptor for a variety of essential lipophilic metabolites, including the steroid hormone estrogen. In the cochlea, megalin is strongly expressed within the marginal cells of the stria vascularis, and previous studies demonstrated that beta-estrogen receptors are also expressed in...

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Identifiers

PMID: 17846082
DOI: 10.1096/fj.07-9171com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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