Article
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).
Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2001
Nykjaer A, Fyfe J C, Kozyraki R, Leheste J R, Jacobsen C, Nielsen M S, Verroust P J, Aminoff M, de la Chapelle A, Moestrup S K, Ray R, Gliemann J, Willnow T E, Christensen E I
Abstract excerpt
Steroid hormones are central regulators of a variety of biological processes. According to the free hormone hypothesis, steroids enter target cells by passive diffusion. However, recently we demonstrated that 25(OH) vitamin D(3) complexed to its plasma carrier, the vitamin D-binding protein, enters renal proximal tubules by receptor-mediated endocytosis. Knockout mice lacking the endocytic receptor megalin lose...
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