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Article

ER stress inhibitor attenuates hearing loss and hair cell death in Cdh23erl/erl mutant mice.

Cell death & disease - 24 Nov 2016

Hu Juan, Li Bo, Apisa Luke, Yu Heping, Entenman Shami, Xu Min, Stepanyan Ruben, Guan Bo-Jhih, Müller Ulrich, Hatzoglou Maria, Zheng Qing Yin

Abstract excerpt

Hearing loss is one of the most common sensory impairments in humans. Mouse mutant models helped us to better understand the mechanisms of hearing loss. Recently, we have discovered that the erlong (erl) mutation of the cadherin23 (Cdh23) gene leads to hearing loss due to hair cell apoptosis. In this study, we aimed to reveal the molecular pathways upstream to apoptosis in hair cells to exploit more effective...

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Identifiers

PMID: 27882946
DOI: 10.1038/cddis.2016.386
PMCID: PMC5260868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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