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Article

Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain.

The Biochemical journal - 1 Oct 2010

Chiu-Ugalde Jazmin, Theilig Franziska, Behrends Thomas, Drebes Julia, Sieland Carolin, Subbarayal Prema, Köhrle Josef, Hammes Annette, Schomburg Lutz, Schweizer Ulrich

Abstract excerpt

Distribution of selenium (Se) within the mammalian body is mediated by SePP (selenoprotein P), an Se-rich glycoprotein secreted by hepatocytes. Genetic and biochemical evidence indicate that the endocytic receptors ApoER2 (apolipoprotein E receptor 2) and megalin mediate tissue-specific SePP upta...

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Identifiers

PMID: 20653565
DOI: 10.1042/BJ20100779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20653565-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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