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Article

Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis.

The Journal of physiology - 1 Oct 2006

Knipper Marlies, Claussen Cathrin, Rüttiger Lukas, Zimmermann Ulrike, Lüllmann-Rauch Renate, Eskelinen Eeva-Liisa, Schröder Jenny, Schwake Michael, Saftig Paul

Abstract excerpt

Our previous studies revealed a critical role of the lysosomal membrane protein LIMP2 in the regulation of membrane transport processes in the endocytic pathway. Here we show that LIMP2-deficient mice display a progressive high-frequency hearing loss and decreased otoacoustic emissions as early a...

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Share to CD36 Antigens
Share to Cochlea
Share to Ear, Inner

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evoked Potentials, Auditory

Share to KCNQ1 Potassium Channel

Share to Low Density Lipoprotein Receptor-Related Protein-2

Share to Lysosomal Membrane Proteins

Share to Potassium Channels, Voltage-Gated

Source

Open in PubMed Open full text

Identifiers

PMID: 16901941
DOI: 10.1113/jphysiol.2006.116889
PMCID: PMC1995639

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16901941-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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