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Article

Association between genetic variants in sortilin-related receptor 1 (SORL1) and Alzheimer's disease in adults with Down syndrome.

Neuroscience letters - 25 Sept 2007

Lee Joseph H, Chulikavit Maruit, Pang Deborah, Zigman Warren B, Silverman Wayne, Schupf Nicole

Abstract excerpt

Recent reports have suggested that variants in the sortilin-related receptor gene (SORL1) increase the risk of late onset Alzheimer's disease (AD) in Northern European, Hispanic, African-American and Isreali-Arab populations. SORL1 directs trafficking of amyloid precursor protein (APP) and under-...

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Source

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Identifiers

PMID: 17826910
DOI: 10.1016/j.neulet.2007.08.042
PMCID: PMC2131721

Genes

SORL1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17826910-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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