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Estrogen receptor DNA binding is not required for estrogen-induced breast cell growth.

Molecular and cellular endocrinology - 15 Oct 2007

DeNardo David G, Cuba Valerie L, Kim HeeTae, Wu Kendall, Lee Adrian V, Brown Powel H

Abstract excerpt

In this study, we determined whether ER DNA binding is necessary for estrogen to stimulate the growth of breast cancer cells. To investigate the requirement of ER DNA binding we expressed either wild-type or a DNA-binding mutant ERalpha in a clone of the MCF-7 breast cancer cell line that no long...

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Identifiers

PMID: 17825481
DOI: 10.1016/j.mce.2007.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17825481-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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