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Article

Regulation of estrogen receptor gene mediated by promoter B responsible for its enhanced expression in human breast cancer

1 Feb 1999

Abstract excerpt

We have previously reported that transcription from a distal promoter (promoter B) of the estrogen receptor alpha (ERalpha) gene is responsible for the increased expression of ERalpha in human breast carcinomas. This paper first characterized the promoter B region in terms of transient transfection experiments with luciferase using MCF-7 cells. Gradual deletions from the 5'-end of promoter B resulted in a...

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PMID: 9889290
DOI: 10.1093/nar/27.3.903

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