Article
Cooperation between the human estrogen receptor (ER) and MCF-7 cell-specific transcription factors elicits high activity of an estrogen-inducible enhancer from the trout ER gene promoter.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 1996
Lazennec G, Kern L, Salbert G, Saligaut D, Valotaire Y
Abstract excerpt
The human estrogen receptor (hER) is expressed in breast cancer MCF-7 cells and plays a major role in tumorigenic processes. In this report, we demonstrate that MCF-7-specific factors can cooperate with the hER to increase its transactivation activity. We previously demonstrated that the rainbow...
Topics
- Animals
- Base Sequence
- Binding Sites
- Breast Neoplasms
- CHO Cells
- Cricetinae
- DNA Footprinting
- DNA-Binding Proteins
- Deoxyribonuclease I
- Enhancer Elements, Genetic
- Estradiol
- Humans
- Liver
- Molecular Sequence Data
- Mutation
- Oncorhynchus mykiss
- Promoter Regions, Genetic
- Receptors, Estrogen