Article
Gene expression profiling reveals that the regulation of estrogen-responsive element-independent genes by 17 beta-estradiol-estrogen receptor beta is uncoupled from the induction of phenotypic changes in cell models.
Journal of molecular endocrinology - 1 May 2008
Li Xiaodong, Nott Stephanie L, Huang Yanfang, Hilf Russell, Bambara Robert A, Qiu Xing, Yakovlev Andrei, Welle Stephen, Muyan Mesut
Abstract excerpt
Estrogen hormone 17beta-estradiol (E(2)) is involved in the physiology and pathology of many tissues. E(2) information is conveyed by the transcription factors estrogen receptors (ER) alpha and beta that mediate a complex array of nuclear and non-nuclear events. The interaction of ER with specific DNA sequences, estrogen-responsive elements (EREs), constitutes a critical nuclear signaling pathway. In addition,...
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