Article
Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography.
Cardiovascular diabetology - 7 Sept 2007
Nemoto Masami, Nishimura Rimei, Sasaki Takashi, Hiki Yoshito, Miyashita Yumi, Nishioka Makiko, Fujimoto Kei, Sakuma Toru, Ohashi Toya, Fukuda Kunihiko, Eto Yoshikatsu, Tajima Naoko
Abstract excerpt
BACKGROUND: Although oxidative stress by accumulation of reactive oxygen species (ROS) in diabetes has become evident, it remains unclear what genes, involved in redox balance, would determine susceptibility for development of atherosclerosis in diabetes. This study evaluated the effect of genetic polymorphism of enzymes producing or responsible for reducing ROS on coronary artery calcification in type 2 diabetes...
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