Genetic association of Glutathione peroxidase-1 (GPx-1) and NAD(P)H:Quinone Oxidoreductase                      1(NQO1) variants and their association of CAD in patients with type-2 diabetes.

doi:10.1007/s11010-011-1098-5

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Article

Genetic association of Glutathione peroxidase-1 (GPx-1) and NAD(P)H:Quinone Oxidoreductase 1(NQO1) variants and their association of CAD in patients with type-2 diabetes.

Molecular and cellular biochemistry - 1 Feb 2012

Ramprasath Tharmarajan, Murugan Ponniah Senthil, Kalaiarasan Ellappan, Gomathi Pannerselvam, Rathinavel Andiappan, Selvam Govindan Sadasivam

Abstract excerpt

Coronary artery disease (CAD) is a major health concern and the leading cause of death in individuals with type-2 diabetes mellitus (T2DM). Glutathione peroxidase-1 (GPx-1) and NAD(P)H: quinone oxidoreductase (NQO1) are known for its broad range of detoxification. The role of functional variants of these genes in the development of various disorders is proven. Hereby, we investigated the possible role of these...

Topics

Adult
Amplified Fragment Length Polymorphism Analysis
Case-Control Studies
Coronary Artery Disease
Diabetes Mellitus, Type 2
Diabetic Angiopathies
Female
Gene Frequency
Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genotype

Glutathione Peroxidase

Humans

India

Lipids

Male

Middle Aged

NAD(P)H Dehydrogenase (Quinone)

Source

Open in PubMed

Identifiers

PMID: 21989715
DOI: 10.1007/s11010-011-1098-5

Genes

CAD
NQO1

Variants

Provenance

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