Article
Glutathione S-transferase T1- and M1-null genotypes and coronary artery disease risk in patients with Type 2 diabetes mellitus.
Pharmacogenomics - 1 Jan 2009
Manfredi Samantha, Calvi Debora, del Fiandra Martina, Botto Nicoletta, Biagini Andrea, Andreassi Maria Grazia
Abstract excerpt
INTRODUCTION: Since long-term exposure to oxidative stress is strongly implicated in the pathogenesis of diabetic complications, polymorphic genes of detoxifying enzymes must be involved in the development of coronary artery disease (CAD). We assessed the potential glutathione S-transferase (GST)...
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