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On the origin of multiple mutant clones in paroxysmal nocturnal hemoglobinuria.

Stem cells (Dayton, Ohio) - 1 Dec 2007

Traulsen Arne, Pacheco Jorge M, Dingli David

Abstract excerpt

The pool of hematopoietic stem cells that actively contributes to hematopoiesis is small, and the cells replicate slowly. Patients with paroxysmal nocturnal hemoglobinuria invariably have a mutation in the PIG-A gene, and many have more than one clone of PIG-A mutated cells. Typically there is a...

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Identifiers

PMID: 17823237
DOI: 10.1634/stemcells.2007-0427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17823237-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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