Article
Long-term support of hematopoiesis by a single stem cell clone in patients with paroxysmal nocturnal hemoglobinuria.
Blood - 15 Apr 2002
Nishimura Ji Jun-ichi, Hirota Toshiyuki, Kanakura Yuzuru, Machii Takashi, Kageyama Takashi, Doi Shoichi, Wada Hiroshi, Masaoka Toru, Kanayama Yoshio, Fujii Hiroshi, Inoue Nobumasa, Kuwayama Maki, Inoue Norimitsu, Ohishi Kazuhito, Kinoshita Taroh
Abstract excerpt
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell disorder characterized by clonal blood cells that are deficient in glycosylphosphatidylinositol-anchored proteins because of somatic mutations of the PIG-A gene. Many patients with PNH have more than one PNH clone, but it is unclear whether a single PNH clone remains dominant or minor clones eventually become dominant. Furthermore,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.