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Article

Evolutionary dynamics of paroxysmal nocturnal hemoglobinuria.

PLoS computational biology - 1 Jun 2018

Mon Père Nathaniel, Lenaerts Tom, Pacheco Jorge M, Dingli David

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder characterized by hemolysis and a high risk of thrombosis, that is due to a deficiency in several cell surface proteins that prevent complement activation. Its origin has been traced to a somatic mutation in the PIG-A gene within hematopoietic stem cells (HSC). However, to date the question of how this mutant clone expands in size to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29912864
DOI: 10.1371/journal.pcbi.1006133
PMCID: PMC6023248

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