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Article

Neutral evolution in paroxysmal nocturnal hemoglobinuria.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 2008

Dingli David, Luzzatto Lucio, Pacheco Jorge M

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria is an acquired hematopoietic stem cell (HSC) disorder characterized by the partial or complete deficiency of glycosyl-phosphatidylinositol (GPI)-linked membrane proteins, which leads to intravascular hemolysis. A loss of function mutation in the PIG-A gene, required for GPI biosynthesis, explains how the deficiency of many membrane proteins can result from a single genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19011109
DOI: 10.1073/pnas.0802749105
PMCID: PMC2587638

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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