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Article

A shuffled CYP1A library shows both structural integrity and functional diversity.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2007

Johnston Wayne A, Huang Weiliang, De Voss James J, Hayes Martin A, Gillam Elizabeth M J

Abstract excerpt

The cytochrome P450 enzymes (P450s) that mediate mammalian xenobiotic metabolism are highly versatile monooxygenases, which show wide and overlapping substrate ranges but generally poor catalytic rates. Re-engineering of these P450s may enable the development of useful biocatalysts for industrial applications. In the current study, restriction enzyme-mediated DNA family shuffling was used to create a library from...

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Identifiers

PMID: 17823232
DOI: 10.1124/dmd.107.017939

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PNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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