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Article

Functionally diverging molecular quasi-species evolve by crossing two enzymes.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2006

Emrén Lars O, Kurtovic Sanela, Runarsdottir Arna, Larsson Anna-Karin, Mannervik Bengt

Abstract excerpt

Molecular evolution is frequently portrayed by structural relationships, but delineation of separate functional species is more elusive. We have generated enzyme variants by stochastic recombinations of DNA encoding two homologous detoxication enzymes, human glutathione transferases M1-1 and M2-2, and explored their catalytic versatilities. Sampled mutants were screened for activities with eight alternative...

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Identifiers

PMID: 16829572
DOI: 10.1073/pnas.0604030103
PMCID: PMC1544140

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Source receipt: pubmed, retrieved 7 Sept 2026.

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