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Article

Extending the diversity of cytochrome P450 enzymes by DNA family shuffling.

Gene - 15 Jun 2007

Rosic Nedeljka N, Huang Weiliang, Johnston Wayne A, DeVoss James J, Gillam Elizabeth M J

Abstract excerpt

The cytochrome P450 enzymes involved in xenobiotic metabolism are an excellent starting point for the directed evolution of novel biocatalysts due to their wide substrate specificity. A shuffled library of three highly homologous mammalian genes (for P450 2C9, P450 2C11 and P450 2C19) was constructed by applying a modified DNA family shuffling procedure. The modifications made to the traditional DNA shuffling...

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Identifiers

PMID: 17400405
DOI: 10.1016/j.gene.2007.01.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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