Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of CYP4B1 enzymes from apes and humans uncovers evolutionary hot spots for adaptations of the catalytical function

27 Jun 2025

Abstract excerpt

A hallmark of the highly conserved CYP4B1 enzyme in mammals is the capability to bioactivate both xenobiotic and endobiotic substrates. However, due to a single amino acid change (p.P427S) within the evolutionary conserved meander region no catalytic activity of the native human CYP4B1 has been identified so far. To identify at which point in human evolution the loss of CYP4B1 activity had occurred, we evaluated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet and metabolism studies
Share to Drug Transport and Resistance Mechanisms
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40577420
DOI: 10.1371/journal.pgen.1011750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of CYP4B1 enzymes from apes and humans uncovers evolutionary hot spots for adaptations of the catalytical functionPMID 40577420Read ↗

Genotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis.Semantic proximity Read ↗

Human CYP7A1 deficiency: progress and enigmas.Semantic proximity Read ↗

Comparative evolutionary pharmacogenetics of CYP2D6 in Ngawbe and Embera Amerindians of Panama and Colombia: role of selection versus drift in world populations.Semantic proximity Read ↗

Pharmacogenetic variation in Neanderthals and Denisovans and implications for human health and response to medicationsSemantic proximity Read ↗

Characterization of Orphan Human Cytochromes P450Semantic proximity Read ↗

CpG site degeneration triggered by the loss of functional constraint created a highly polymorphic macaque drug-metabolizing gene, CYP1A2.Semantic proximity Read ↗

Characterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and HumanSemantic proximity Read ↗

CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkeySemantic proximity Read ↗

The role of aldehyde oxidase in drug metabolism.Semantic proximity Read ↗

Genes Encoding Xenobiotic Detoxification Proteins evolve by gene death, duplication and positive selectionSemantic proximity Read ↗

Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotesSemantic proximity Read ↗

A shuffled CYP1A library shows both structural integrity and functional diversity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.