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Article

Generation, validation, and application of a P450 homology model.

Current topics in medicinal chemistry - 1 Jan 2013

Lewis Benjamin C, Miners John O

Abstract excerpt

In vitro validation of a protein homology model is critical for determining the predictivity of a computationally generated structure. Here we discuss the generation, validation, and application of a homology model for CYP1A1. Validation of the CYP1A1 homology model, generated using the highly homologous crystal template of human CYP1A2 (pdb 2HI4), was achieved using the prototypic substrate 7-ethoxyresorufin...

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Identifiers

PMID: 24047137
DOI: 10.2174/15680266113136660156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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