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Article

A novel p21 attenuator which is structurally related to sorafenib

8 Jan 2013

Abstract excerpt

p21 is a member of the cyclin kinase inhibitor family of proteins and plays pivotal roles in cellular proliferation as well as in the regulation of apoptosis, and thus has diverse functions in diseases as varied as cancer and atherosclerosis. In light of its pleiotropic effects and potential clinical relevance, new methods of attenuation of p21 protein levels by selective inhibitors are therefore powerful tools...

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PMID: 23298903
DOI: 10.4161/cbt.23374

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