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Article

Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes.

Experimental hematology - 1 Dec 2012

Novak Rachel L, Harper David P, Caudell David, Slape Christopher, Beachy Sarah H, Aplan Peter D

Abstract excerpt

NUP98-HOXD13 (NHD13) and CALM-AF10 (CA10) are oncogenic fusion proteins produced by recurrent chromosomal translocations in patients with acute myeloid leukemia (AML). Transgenic mice that express these fusions develop AML with a long latency and incomplete penetrance, suggesting that collaborating genetic events are required for leukemic transformation. We employed genetic techniques to identify both preleukemic...

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Share to Cell Transformation, Neoplastic
Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Gene Knockdown Techniques

Share to Leukemia

Share to Leukemia, Myeloid, Acute

Share to Myeloid Ecotropic Viral Integration Site 1 Protein

Share to Oncogene Proteins, Fusion

Source

Open in PubMed Open full text

Identifiers

PMID: 22885519
DOI: 10.1016/j.exphem.2012.08.001
PMCID: PMC3496069

Genes

HOXD13
NUP98

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes.PMID 22885519Read ↗

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