Consistent detection of <i>CALM‐AF10</i> chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts

Abstract excerpt

The t(10;11)(p13-14;q14-21) is a rare but recurring translocation associated with acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML). Recently the CALM gene was cloned from the t(10;11) breakpoint of U937 and fused to AF10, a putative transcription factor, which had been identified as one of the fusion partners of the MLL gene. In order to define the involvement of these genes in primary...

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