Article
Association between restriction fragment length polymorphism of the human cytochrome P450IIE1 gene and susceptibility to alcoholic liver cirrhosis.
The American journal of gastroenterology - 1 Apr 1994
Maezawa Y, Yamauchi M, Toda G
Abstract excerpt
OBJECTIVES: Cytochrome P450IIE1 (P450IIE1) is involved in ethanol metabolism and in the metabolic activation of carcinogenic nitrosoamines. The purpose of our investigation was to determine whether P450IIE1 restriction fragment length polymorphisms (RFLP) were associated with the development of a...
Topics
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Disease Susceptibility
- Fatty Liver, Alcoholic
- Genotype
- Humans
- Japan
- Liver Cirrhosis, Alcoholic
- Male
- Middle Aged
- Oxidoreductases, N-Demethylating
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length