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Article

Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute colitis in mice.

International journal of molecular medicine - 1 Oct 2007

Bank Ute, Tadje Janine, Täger Michael, Wolke Carmen, Bukowska Alicja, Ittenson Annelore, Reinhold Dirk, Helmuth Martin, Ansorge Siegfried, Shakespeare Ann, Vieth Michael, Malfertheiner Peter, Naumann Michael, Lendeckel Uwe

Abstract excerpt

Inhibitors of alanyl-aminopeptidase e.g. phebestin increase the expression of transforming growth factor (TGF)-beta1 in mononuclear cells. We investigated whether phebestin also produced this effect in CD4+CD25+ T-cells and whether phebestin-treated CD4+CD25+ T-cells were capable of ameliorating acute colitis in mice. The suppressive activity of mouse CD4+CD25+ T-cells was assessed in vitro by co-culture with...

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PMID: 17786278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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