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Article

The impact of regulatory T cells on carcinogen-induced sarcogenesis

1 Jun 2007

Abstract excerpt

Burnet proposed in the 1950's that the immune system is engaged in identifying and destroying abnormal cancerous cells. This process, termed immune surveillance, has been at the centre of intense debate for decades. Results using immunodeficient mice lend support to the immune surveillance hypothesis. We surmised that immune surveillance would be hampered by the inhibitory effect of naturally occurring FoxP3(+)...

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PMID: 17565340
DOI: 10.1038/sj.bjc.6603824

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