Enhancement of regulatory T cell-like suppressive function in MT-2 by long-term and low-dose exposure to asbestos.

doi:10.1016/j.tox.2015.10.005

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Enhancement of regulatory T cell-like suppressive function in MT-2 by long-term and low-dose exposure to asbestos.

Toxicology - 2 Dec 2015

Ying Chen, Maeda Megumi, Nishimura Yasumitsu, Kumagai-Takei Naoko, Hayashi Hiroaki, Matsuzaki Hidenori, Lee Suni, Yoshitome Kei, Yamamoto Shoko, Hatayama Tamayo, Otsuki Takemi

Abstract excerpt

Asbestos exposure causes lung fibrosis and various malignant tumors such as lung cancer and malignant mesothelioma. The effects of asbestos on immune cells have not been thoroughly investigated, although our previous reports showed that asbestos exposure reduced anti-tumor immunity. The effects of continuous exposure of regulatory T cells (Treg) to asbestos were examined using the HTLV-1 immortalized human T cell...

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Enhancement of regulatory T cell-like suppressive function in MT-2 by long-term and low-dose exposure to asbestos.

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