Article
Accelerated chemically induced tumor development mediated by CD4+CD25+ regulatory T cells in wild-type hosts.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2005
Nishikawa Hiroyoshi, Kato Takuma, Tawara Isao, Takemitsu Tetsushi, Saito Kanako, Wang Linan, Ikarashi Yoshinori, Wakasugi Hiro, Nakayama Toshinori, Taniguchi Masaru, Kuribayashi Kagemasa, Old Lloyd J, Shiku Hiroshi
Abstract excerpt
We examined the role of CD4+CD25+ regulatory T cells in the development of 3-methylcholanthrene (MCA)-induced tumors. Immunization of wild-type BALB/c mice with a series of SEREX (serological identification of antigens by recombinant expression cloning)-defined broadly expressed self-antigens results in the development of highly active CD4+CD25+ regulatory T cells. Accelerated tumor development was observed in...
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